Cleared Traditional

K251903 - Erchonia DPN Laser (Model# EVRL) (FDA 510(k) Clearance)

Class II Physical Medicine device cleared through predicate-based substantial equivalence.

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Feb 2026
Decision
244d
Days
Class 2
Risk

K251903 is an FDA 510(k) clearance for the Erchonia DPN Laser (Model# EVRL). Classified as Powered Light Based Laser Non-thermal Instrument With Non-heating Effect For Adjunctive Use In Pain Therapy (product code NHN), Class II - Special Controls.

Submitted by Erchonia Corporation (Fountain Inn, US). The FDA issued a Cleared decision on February 19, 2026 after a review of 244 days - an extended review cycle.

This device falls under the Physical Medicine FDA review panel, regulated under 21 CFR 890.5500 - the FDA physical medicine device framework. The Traditional 510(k) pathway establishes clearance through substantial equivalence to a legally marketed predicate device, without requiring clinical trial data.

Device pattern: Standard predicate-based submission. Standard predicate reliance. This clearance follows a standard predicate-based equivalence path within the Physical Medicine review framework, consistent with the majority of Class II 510(k) submissions.

View all Erchonia Corporation devices

Submission Details

510(k) Number K251903 FDA.gov
FDA Decision Cleared Substantially Equivalent - Traditional 510(k) (SESE)
Date Received June 20, 2025
Decision Date February 19, 2026
Days to Decision 244 days
Submission Type Traditional
Review Panel Physical Medicine (PM)
Summary Summary PDF
Third-party Review No - reviewed directly by FDA
Combination Product No
PCCP Authorized No
Regulatory Context
Review time vs. panel average
129d slower than avg
Panel avg: 115d · This submission: 244d
Pathway characteristics
Predicate-based equivalence.

Device Classification

Product Code NHN Powered Light Based Laser Non-thermal Instrument With Non-heating Effect For Adjunctive Use In Pain Therapy
Device Class Class 2 - Special Controls
CFR Regulation 21 CFR 890.5500
Definition A Laser (light Amplification By Stimulated Emission Of Radiation) Based Device Having Coherence, Collimated And Typically Monochromatic Radiation. This Device Emits Energy In The Infrared Or Other Wavelengths, Provides Non-heating And Non-thermal Effect, And Is Indicated For Adjunctive Use In Pain Therapy Or Related Indication. It Does Not Provide Therapeutic Topical Heating. The Classification Regulation For Infrared Lamps Describes A Device That Emits Energy In The Infrared Wavelength To Provide Topical Heating And That Is Not Limited To Adjunctive Use.
What this classification means

Class II devices require demonstration of substantial equivalence to a legally marketed predicate device. Clinical trial data may be submitted as supporting evidence to strengthen the substantial equivalence argument. Most Physical Medicine devices follow this clearance model.

Clinical Evidence

ClinicalTrials.gov
NCT05291975 Completed Interventional Industry-sponsored

Clinical Efficacy and Human Factors Validation Testing of the Erchonia EVRL for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain

Clinical Efficacy and Human Factors Validation Testing for Prescription Home Use of the Erchonia Corporation EVRL™ for Providing Temporary Relief of Diabetic Peripheral Neuropathy Foot Pain

64
Patients (actual)
4
Sites
Treatment
Purpose
Triple
Masking
Condition studied Neuropathy, Diabetic; Neuropathy;Peripheral; Neuropathy, Painful
Study design Parallel
Eligibility All sexes · 18 Years+
Sponsor Erchonia Corporation (industry)
Started 2022-02-17 Primary completion 2024-10-16 Completed 2024-12-12
Primary outcome
Number of Participants With a 30% or Greater Change in Pain Rating on the Visual Analog Scale (VAS)
Secondary outcome
Satisfaction With Study Outcome
View full study on ClinicalTrials.gov

Regulatory Peers - NHN Powered Light Based Laser Non-thermal Instrument With Non-heating Effect For Adjunctive Use In Pain Therapy

All 52
Devices cleared under the same product code (NHN) and FDA review panel - the closest regulatory comparables to K251903.
Therapy US
K252273 · Dmc Importa??o E Exporta??o DE Equipamentos Ltda · Dec 2025
Enhanced Handheld Pain Relief Laser Instrument (GD-P-E)
K241057 · Wuhan Guangdun Technology Co.,Ltd.. · Jan 2025
Therapy EC, Therapy XT
K232813 · Dmc Importacao E Exportacao DE Equipamentos Ltda · Dec 2024
Erchonia FX-405
K231409 · Erchonia Corporation · Aug 2023
Erchonia GVL
K221987 · Erchonia Corporation · Sep 2022
Erchonia FX-405
K212595 · Erchonia Corporation · Nov 2021