QOF · Class II · 21 CFR 866.3981

FDA Product Code QOF: Multi-target Respiratory Specimen Nucleic Acid Test Including Sars-cov-2 And Other Microbial Agents

FDA product code QOF covers multi-target respiratory specimen nucleic acid tests.

These multiplex molecular assays simultaneously detect and identify multiple respiratory pathogens — including influenza A/B, RSV, SARS-CoV-2, and others — from a single patient sample. They provide faster and more comprehensive results than single-target tests, enabling rapid differentiation of respiratory illnesses.

QOF devices are Class II medical devices, regulated under 21 CFR 866.3981 and reviewed by the FDA Microbiology panel.

Leading manufacturers include Biofire Diagnostics, LLC, Roche Molecular Systems, Inc. and Cepheid.

17
Total
16
Cleared
158d
Avg days
2021
Since

List of Multi-target Respiratory Specimen Nucleic Acid Test Including Sars-cov-2 And Other Microbial Agents devices cleared through 510(k)

17 devices
1–17 of 17
Cleared Aug 14, 2025
BIOFIRE SPOTFIRE Respiratory/Sore Throat Panel Mini
K243544
Biofire Diagnostics, LLC
Microbiology · 272d
Cleared Jul 31, 2025
cobas Respiratory 4-flex for use on the cobas 5800/6800/8800 Systems
K243455
Roche Molecular Systems, Inc.
Microbiology · 266d
Cleared May 01, 2025
Xpert Xpress CoV-2/Flu/RSV plus
K250995
Cepheid
Microbiology · 30d
Cleared May 01, 2025
Xpert Xpress CoV-2/Flu/RSV plus
K250996
Cepheid
Microbiology · 30d
Cleared Apr 25, 2025
cobas liat SARS-CoV-2 & Influenza A/B v2 nucleic acid test
K243400
Roche Molecular Systems, Inc.
Microbiology · 176d
Cleared Apr 25, 2025
cobas liat SARS-CoV-2, Influenza A/B & RSV nucleic acid test
K243406
Roche Molecular Systems, Inc.
Microbiology · 175d
Cleared Jan 10, 2025
Xpert Xpress CoV-2/Flu/RSV plus
K242071
Cepheid
Microbiology · 178d
Cleared Nov 15, 2024
Panther Fusion SARS-CoV-2/Flu A/B/RSV assay
K242465
Hologic, Inc.
Microbiology · 87d
Cleared Jul 18, 2024
Panther Fusion SARS-CoV-2/Flu A/B/RSV Assay
K241240
Hologic, Inc.
Microbiology · 76d
Cleared May 30, 2024
BIOFIRE SPOTFIRE Respiratory/Sore Throat (R/ST) Panel Mini
K241194
Biofire Diagnostics, LLC
Microbiology · 30d
Cleared Mar 26, 2024
BIOFIRE SPOTFIRE Respiratory/Sore Throat (R/ST) Panel
K232954
Biofire Diagnostics, LLC
Microbiology · 187d
Cleared Mar 11, 2024
NxTAG Respiratory Pathogen Panel v2 (NxTAG RPP v2)
K231758
Luminex Molecular Diagnostics, Inc.
Microbiology · 269d
Cleared Aug 17, 2023
Xpert Xpress CoV-2/Flu/RSV plus
K231481
Cepheid
Microbiology · 86d
Cleared Jul 27, 2023
cobas® SARS-CoV-2 & Influenza A/B Nucleic acid test for use on the cobas® Liat® System
K223591
Roche Molecular Systems, Inc.
Microbiology · 238d
Cleared May 16, 2023
Panther Fusion SARS-CoV-2/Flu A/B/RSV Assay
K222736
Hologic, Inc.
Microbiology · 249d
Cleared Apr 13, 2023
BIOFIRE® SPOTFIRE® Respiratory (R) Panel Mini
K230719
Biofire Diagnostics, LLC
Microbiology · 29d
Not Cleared Mar 17, 2021
BioFire Respiratory Panel 2.1 (RP2.1)
DEN200031
Biofire Diagnostics, LLC
Microbiology · 302d

How to use this database

This page lists all FDA 510(k) submissions for Multi-target Respiratory Specimen Nucleic Acid Test Including Sars-cov-2 And Other Microbial Agents devices (product code QOF). Click any device to view full submission details, including the decision date, manufacturer information, predicate device, and a link to the official FDA record.

These devices fall under the Microbiology FDA review panel. Browse all Microbiology devices →