HSN · Class II · 21 CFR 888.3110

FDA Product Code HSN: Prosthesis, Ankle, Semi-constrained, Cemented, Metal/polymer

Total ankle replacement has gained significant momentum as an alternative to arthrodesis. FDA product code HSN covers semi-constrained cemented ankle prostheses with metal-polymer bearing surfaces.

These three-component implants replace the tibial plafond and talar dome surfaces to restore pain-free ankle motion while preserving the natural kinematics of the joint. They offer improved gait compared to ankle fusion in appropriately selected patients with end-stage ankle arthritis.

HSN devices are Class II medical devices, regulated under 21 CFR 888.3110 and reviewed by the FDA Orthopedic panel.

Leading manufacturers include Paragon 28, Inc., Restor3d and Wrightmedicaltechnologyinc.

67
Total
67
Cleared
129d
Avg days
1976
Since
Stable submission activity - 8 submissions in the last 2 years
Review times improving: avg 111d recently vs 132d historically

FDA 510(k) Cleared Prosthesis, Ankle, Semi-constrained, Cemented, Metal/polymer Devices (Product Code HSN)

67 devices
1–24 of 67
Cleared Sep 03, 2025
Kinos Total Ankle System
K252454
Restor3d
Orthopedic · 30d
Cleared Jun 20, 2025
Incompass Total Ankle System
K250037
Wright Medical Technology, Inc. (Stryker)
Orthopedic · 163d
Cleared May 01, 2025
APEX 3D Total Ankle Replacement System
K250641
Paragon 28, Inc.
Orthopedic · 58d
Cleared Dec 02, 2024
Hintermann Series H2 Total Ankle System
K240475
Vilex, LLC
Orthopedic · 286d
Cleared Nov 01, 2024
Prophecy Surgical Planning System
K241999
Wright Medical Technology, Inc. (Stryker)
Orthopedic · 115d
Cleared Oct 18, 2024
Kinos Total Ankle System
K242868
Restor3d
Orthopedic · 28d
Cleared Jul 22, 2024
Kinos Total Ankle System
K241482
Restor3d
Orthopedic · 59d
Cleared Jun 24, 2024
APEX 3D Total Ankle Replacement System
K240259
Paragon 28, Inc.
Orthopedic · 145d
Cleared Apr 29, 2024
restor3d Kinos Axiom Total Ankle System
K240591
Restor3D, Inc.
Orthopedic · 59d
Cleared Apr 23, 2024
QUANTUM® Patient Specific Instrumentation (PSI) System
K231699
In2bones Sas
Orthopedic · 316d
Cleared Nov 28, 2023
Kinos Axiom Total Ankle System
K232595
Restor3d
Orthopedic · 95d
Cleared Oct 12, 2023
Exactech® Vantage® Total Ankle System
K230717
Exactech, Inc.
Orthopedic · 211d
Cleared Sep 11, 2023
Vantage® Total Ankle System
K232002
Exactech, Inc.
Orthopedic · 68d
Cleared Jul 17, 2023
OPTIX H2 Patient Specific Instrument System
K230462
Vilex, LLC
Orthopedic · 146d
Cleared Apr 06, 2023
QUANTUM Patient Specific Instrumentation (PSI) System
K230313
In2bones Sas
Orthopedic · 59d
Cleared Jan 27, 2023
Prophecy Preoperative Navigation Alignment System
K222835
Wrightmedicaltechnologyinc
Orthopedic · 129d
Cleared Nov 17, 2022
MAVEN™ Patient-Specific Instrumentation
K223227
Paragon 28, Inc.
Orthopedic · 30d
Cleared Mar 10, 2021
PROPHECY Preoperative Navigation Alignment System
K202815
Wrightmedicaltechnologyinc
Orthopedic · 167d
Cleared Mar 06, 2021
Apex 3D Total Ankle Replacement System
K210390
Paragon 28, Inc.
Orthopedic · 25d
Cleared Jan 14, 2021
Maven Patient-Specific Instrumentation
K202019
Paragon 28, Inc.
Orthopedic · 177d

About Product Code HSN - Regulatory Context

510(k) Submission Activity

67 total 510(k) submissions under product code HSN since 1976, with 67 receiving FDA clearance (average review time: 129 days).

Submission volume has remained relatively stable over the observed period, with 8 submissions in the last 24 months.

FDA Review Time

Recent submissions under HSN have taken an average of 111 days to reach a decision - down from 132 days historically, suggesting improved FDA processing for this classification.

HSN devices are reviewed by the Orthopedic panel. Browse all Orthopedic devices →