IYE · Class II · 21 CFR 892.5050

FDA Product Code IYE: Accelerator, Linear, Medical

Medical linear accelerators are the cornerstone of modern radiation oncology. FDA product code IYE covers medical linear accelerators used for external beam radiation therapy.

These systems generate high-energy X-ray or electron beams to destroy cancer cells while minimizing damage to surrounding healthy tissue. Advanced systems incorporate image guidance, intensity modulation, and stereotactic radiosurgery capabilities for highly precise dose delivery.

IYE devices are Class II medical devices, regulated under 21 CFR 892.5050 and reviewed by the FDA Radiology panel.

Leading manufacturers include Varian Medical Systems, Inc., Brainlab AG and Elekta Solutions AB.

731
Total
731
Cleared
130d
Avg days
1977
Since
Declining activity - 21 submissions in the last 2 years vs 31 in the prior period
Review times increasing: avg 159d recently vs 129d historically

FDA 510(k) Cleared Accelerator, Linear, Medical Devices (Product Code IYE)

731 devices
1–24 of 731
Cleared Apr 15, 2026
VERIQA RT EPID 3D
K252258
Ptw-Freiburg Physikalisch-Technische-Werkstaetten Dr. Pychla
Radiology · 268d
Cleared Apr 03, 2026
ClearCheck (RADCC V2.7)
K253962
Radformation, Inc.
Radiology · 113d
Cleared Mar 18, 2026
AlignRT Plus (8.0)
K253012
Vision Rt, Ltd.
Radiology · 180d
Cleared Jan 21, 2026
Halcyon, Ethos Radiotherapy System (5.0)
K252977
Varian Medical Systems, Inc.
Radiology · 126d
Cleared Jan 15, 2026
EMLA (Elekta Evo)
K252188
Elekta Solutions AB
Radiology · 185d
Cleared Jan 14, 2026
ExacTrac Dynamic (2.0.2)
K254010
Brainlab SE
Radiology · 30d
Cleared Jan 05, 2026
ChartCheck (RADCH V1.6)
K252988
Radformation, Inc.
Radiology · 109d
Cleared Dec 16, 2025
IDENTIFY (5.0)
K252919
Varian Medical Systems, Inc.
Radiology · 95d
Cleared Nov 03, 2025
ZAP-X Radiosurgery System (ZAP-X)
K250392
Zap Surgical Systems, Inc.
Radiology · 264d
Cleared Oct 24, 2025
AccuCheck
K250696
Manteia Technologies Co., Ltd.
Radiology · 231d
Cleared Oct 17, 2025
MOSkin Radiation Measurement System
K250911
Electrogenics Labs, Ltd.
Radiology · 205d
Cleared Oct 07, 2025
TrueBeam, TrueBeam STX, Edge and VitalBeam
K252948
Varian Medical Systems, Inc.
Radiology · 21d
Cleared Sep 03, 2025
AquaCast Mask
K252174
Blessing Cathay Corporation
Radiology · 54d
Cleared Jun 23, 2025
Cranial 4Pi Immobilization
K243142
Brainlab AG
Radiology · 266d
Cleared May 19, 2025
MapRT
K243301
Vision Rt, Ltd.
Radiology · 213d
Cleared May 16, 2025
Mobius3D (4.1)
K250099
Varian Medical Systems
Radiology · 122d
Cleared Mar 19, 2025
DSPS-Prominent® baseplate, MR (113820)
K250429
Macromedics BV
Radiology · 33d
Cleared Mar 18, 2025
Klarity SGRT System (ARSG-E1A, ARSG-E3A)
K241937
Klarity Medical & Equipment (GZ) Co., Ltd.
Radiology · 259d
Cleared Feb 07, 2025
Identify (4.0)
K242957
Varian Medical Systems, Inc.
Radiology · 135d
Cleared Jul 24, 2024
ExacTrac Dynamic (2.0)
K240431
Brainlab AG
Radiology · 161d
Cleared May 31, 2024
BeamDose software (S080053)
K232738
Ptw-Freiburg Physikalisch-Technische-Werkstaetten Dr. Pychla
Radiology · 267d
Cleared Apr 30, 2024
Ethos Treatment Management (3.0)
K232923
Varian Medical Systems, Inc.
Radiology · 224d
Cleared Apr 12, 2024
VenusX
K232489
Linatech, LLC
Radiology · 239d
Cleared Mar 29, 2024
LUNA 3D
K232031
Lap GmbH Laser Applikationen
Radiology · 266d

About Product Code IYE - Regulatory Context

510(k) Submission Activity

731 total 510(k) submissions under product code IYE since 1977, with 731 receiving FDA clearance (average review time: 130 days).

Submission volume has declined in recent years - 21 submissions in the last 24 months compared to 31 in the prior period.

FDA Review Time

Recent submissions under IYE have taken an average of 159 days to reach a decision - up from 129 days historically. Manufacturers should account for longer review timelines in current project planning.

IYE devices are reviewed by the Radiology panel. Browse all Radiology devices →