Cleared Traditional

K221590 - NaviCam Small Bowel Capsule Endoscopy System (FDA 510(k) Clearance)

Class II Gastroenterology & Urology device cleared through predicate-based substantial equivalence.

Download Printable Device Report (PDF)
Optimized for regulatory review, auditing and printing
Dec 2022
Decision
183d
Days
Class 2
Risk

K221590 is an FDA 510(k) clearance for the NaviCam Small Bowel Capsule Endoscopy System. Classified as System, Imaging, Gastrointestinal, Wireless, Capsule (product code NEZ), Class II - Special Controls.

Submitted by Ankon Technologies Co., Ltd. (Wuhan, CN). The FDA issued a Cleared decision on December 2, 2022 after a review of 183 days - an extended review cycle.

This device falls under the Gastroenterology & Urology FDA review panel, regulated under 21 CFR 876.1300 - the FDA gastroenterology and urology device framework. The Traditional 510(k) pathway establishes clearance through substantial equivalence to a legally marketed predicate device, without requiring clinical trial data.

Device pattern: Standard predicate-based submission. Standard predicate reliance. This clearance follows a standard predicate-based equivalence path within the Gastroenterology & Urology review framework, consistent with the majority of Class II 510(k) submissions.

View all Ankon Technologies Co., Ltd. devices

Submission Details

510(k) Number K221590 FDA.gov
FDA Decision Cleared Substantially Equivalent - Traditional 510(k) (SESE)
Date Received June 02, 2022
Decision Date December 02, 2022
Days to Decision 183 days
Submission Type Traditional
Review Panel Gastroenterology & Urology (GU)
Summary Summary PDF
Third-party Review No - reviewed directly by FDA
Combination Product No
PCCP Authorized No
Regulatory Context
Review time vs. panel average
53d slower than avg
Panel avg: 130d · This submission: 183d
Pathway characteristics
Predicate-based equivalence.

Device Classification

Product Code NEZ System, Imaging, Gastrointestinal, Wireless, Capsule
Device Class Class 2 - Special Controls
CFR Regulation 21 CFR 876.1300
What this classification means

Class II devices require demonstration of substantial equivalence to a legally marketed predicate device. Clinical trial data may be submitted as supporting evidence to strengthen the substantial equivalence argument. Most Gastroenterology & Urology devices follow this clearance model.

Regulatory Consultant

ProMedoss, Inc.
Shoshana Friedman

The regulatory consultant manages the 510(k) submission process on behalf of the applicant - coordinating technical documentation, predicate strategy and FDA communications. Identifying the consultant behind a submission is a key signal for competitive regulatory intelligence.

Clinical Evidence

ClinicalTrials.gov
NCT05086471 Completed Interventional

Performance Evaluation of the NaviCam SB Capsule Endoscope System for the Diagnosis of Small Bowel Diseases

Performance Evaluation of the NaviCam SB Capsule Endoscope System in Comparison to the PillCam SB3 Capsule System for the Diagnosis of Small Bowel Diseases

87
Patients (actual)
1
Site
Diagnostic
Purpose
Open label
Masking
Condition studied Small Bowel Disease
Study design Single group
Eligibility All sexes · 18 Years+
Principal investigator XiaoHua Hou, MD.PhD
Sponsor Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Started 2021-09-23 Primary completion 2021-12-01 Completed 2021-12-30
Primary outcome
Diagnostic agreement rate
Secondary outcome
Intestinal transit time
Study completed - no results published. This trial concluded in 2021 but has not posted results to ClinicalTrials.gov. Completed studies without public results are common in industry-sponsored device trials; the data may be referenced in the 510(k) Summary PDF or remain unpublished. Individual participant data will not be shared.
View full study on ClinicalTrials.gov

Regulatory Peers - NEZ System, Imaging, Gastrointestinal, Wireless, Capsule

All 45
Devices cleared under the same product code (NEZ) and FDA review panel - the closest regulatory comparables to K221590.
CE Deliver (DLV)
K252480 · CapsoVision, Inc. · Dec 2025
CapsoCam Plus (SV-3) Capsule Endoscopy System
K242643 · CapsoVision, Inc. · Dec 2024
PillCam™ Genius SB System with PillCam Software v9.7 and PillCam Cloud Reader Software
K240276 · Given Imaging Ltd. (D.B.A. Medtronic) · May 2024
NaviCam Small Bowel Capsule Endoscopy System with NaviCam SB Capsule and NaviCam Tether
K233229 · Anx Robotica Corporation · Jan 2024
PillCam SB 3 capsule endoscopy system, PillCam Software 9.0E
K230991 · Given Imaging Ltd. (Medtronic) · Jun 2023
PillCam SB 3 capsule endoscopy system, PillCam Software 9.0E
K211684 · Given Imaging Ltd. (Medtronic) · Aug 2021