Cleared Traditional

K240544 - Epitomee (FDA 510(k) Clearance)

Class II Gastroenterology & Urology device cleared through predicate-based substantial equivalence.

Download Printable Device Report (PDF)
Optimized for regulatory review, auditing and printing
Sep 2024
Decision
199d
Days
Class 2
Risk

K240544 is an FDA 510(k) clearance for the Epitomee. Classified as Ingested, Transient, Space Occupying Device For Weight Management And/or Weight Loss (product code QFQ), Class II - Special Controls.

Submitted by Epitomee Medical , Ltd. (Caesarea, IL). The FDA issued a Cleared decision on September 13, 2024 after a review of 199 days - an extended review cycle.

This device falls under the Gastroenterology & Urology FDA review panel, regulated under 21 CFR 876.5982 - the FDA gastroenterology and urology device framework. The Traditional 510(k) pathway establishes clearance through substantial equivalence to a legally marketed predicate device, without requiring clinical trial data.

Device pattern: Standard predicate-based submission. Standard predicate reliance. This clearance follows a standard predicate-based equivalence path within the Gastroenterology & Urology review framework, consistent with the majority of Class II 510(k) submissions.

View all Epitomee Medical , Ltd. devices

Submission Details

510(k) Number K240544 FDA.gov
FDA Decision Cleared Substantially Equivalent - Traditional 510(k) (SESE)
Date Received February 27, 2024
Decision Date September 13, 2024
Days to Decision 199 days
Submission Type Traditional
Review Panel Gastroenterology & Urology (GU)
Summary Summary PDF
Third-party Review No - reviewed directly by FDA
Combination Product No
PCCP Authorized No
Regulatory Context
Review time vs. panel average
69d slower than avg
Panel avg: 130d · This submission: 199d
Pathway characteristics
Predicate-based equivalence.

Device Classification

Product Code QFQ Ingested, Transient, Space Occupying Device For Weight Management And/or Weight Loss
Device Class Class 2 - Special Controls
CFR Regulation 21 CFR 876.5982
Definition This Device Is An Ingested Material That Transiently Occupies Space In The Stomach. The Device Passes From The Body Via The Natural Gastrointestinal Tract.
What this classification means

Class II devices require demonstration of substantial equivalence to a legally marketed predicate device. Clinical trial data may be submitted as supporting evidence to strengthen the substantial equivalence argument. Most Gastroenterology & Urology devices follow this clearance model.

Regulatory Consultant

Hogan Lovells US LLP
Janice Hogan

The regulatory consultant manages the 510(k) submission process on behalf of the applicant - coordinating technical documentation, predicate strategy and FDA communications. Identifying the consultant behind a submission is a key signal for competitive regulatory intelligence.

Clinical Evidence

ClinicalTrials.gov
NCT03610958 Completed Interventional Industry-sponsored

Safety and Performance Evaluation of the Epitomee Device for Enhancing Satiety and Weight Loss.

Prospective, Single Center, Open-labeled Single Arm Study, to Asses the Safety and Performance Evaluation of the Epitomee Device for Enhancing Satiety and Weight Loss in Healthy Over Weight and Obese Subjects

78
Patients (actual)
1
Site
Treatment
Purpose
Open label
Masking
Condition studied Overweight; Obesity
Study design Single group
Eligibility All sexes · 21 Years+ · Healthy volunteers accepted
Principal investigator Haim Shirin, MD
Sponsor Epitomee medical (industry)
Started 2014-09-04 Primary completion 2018-09-04
Primary outcome
Safety evaluation of the Device administration.
Study completed - no results published. This trial concluded in 2018 but has not posted results to ClinicalTrials.gov. Completed studies without public results are common in industry-sponsored device trials; the data may be referenced in the 510(k) Summary PDF or remain unpublished.
View full study on ClinicalTrials.gov

Regulatory Peers - QFQ Ingested, Transient, Space Occupying Device For Weight Management And/or Weight Loss

Devices cleared under the same product code (QFQ) and FDA review panel - the closest regulatory comparables to K240544.
Plenity
K230133 · Gelesis, Inc. · Jan 2024