FDA Product Code NPL: Barrier, Animal Source, Intraoral

FDA product code NPL covers animal-derived intraoral barriers used in dental procedures.

These natural membrane materials — typically derived from bovine or porcine collagen — are used as resorbable barriers in guided bone regeneration and guided tissue regeneration procedures. They separate epithelial tissue from bone defects, allowing selective repopulation by osteogenic cells.

NPL devices are Class II medical devices, regulated under 21 CFR 872.3930 and reviewed by the FDA Dental panel.

Leading manufacturers include Geistlich Pharma AG, Neo Modulus (Suzhou) Medical Sci-Tech Co., Ltd. and Institut Straumann AG.