ONB · Class II · 21 CFR 880.5440

FDA Product Code ONB: Closed Antineoplastic And Hazardous Drug Reconstitution And Transfer System

Handling hazardous chemotherapy drugs poses significant risks to healthcare workers. FDA product code ONB covers closed-system drug reconstitution and transfer devices for antineoplastic and hazardous drugs.

These systems mechanically prevent the escape of hazardous vapors and aerosols during the preparation and transfer of chemotherapy agents, protecting pharmacy staff and nurses from toxic exposure while maintaining drug sterility.

ONB devices are Class II medical devices, regulated under 21 CFR 880.5440 and reviewed by the FDA General Hospital panel.

Leading manufacturers include Epic Medical Pte. , Ltd., Simplivia Healthcare , Ltd. and Care Fusion.

41
Total
41
Cleared
198d
Avg days
2013
Since
Growing category - 12 submissions in the last 2 years vs 6 in the prior period
Review times improving: avg 111d recently vs 234d historically

FDA 510(k) Cleared Closed Antineoplastic And Hazardous Drug Reconstitution And Transfer System Devices (Product Code ONB)

41 devices
1–24 of 41
Cleared Dec 05, 2025
ProSeal™ Transfer Injector (421120, 421130, 421140)
K251722
Epic Medical Pte. , Ltd.
General Hospital · 184d
Cleared Oct 21, 2025
Chemfort® 28-day 20 mm Vial Adaptor and 13 mm Convertor
K253033
Simplivia Healthcare , Ltd.
General Hospital · 29d
Cleared Sep 12, 2025
BD PhaSeal™ Optima Connecting Set (C83-O)
K250059
Becton, Dickinson and Company
General Hospital · 245d
Cleared Aug 05, 2025
Chemfort Female Luer Lock Adaptor
K251411
Simplivia Healthcare , Ltd.
General Hospital · 90d
Cleared May 29, 2025
ProSeal™ Bag Spike with Additive Port (423370ST, 423370)
K251340
Epic Medical Pte. , Ltd.
General Hospital · 29d
Cleared Jan 22, 2025
ZeroClear™ Bag Access (423100)
K243976
Epic Medical Pte. , Ltd.
General Hospital · 30d
Cleared Dec 26, 2024
ProSeal™ Vented Universal Vial Adaptor
K240517
Epic Medical Pte. , Ltd.
General Hospital · 307d
Cleared Oct 23, 2024
ProSeal™ Closed System Bag Access
K241988
Epic Medical Pte. , Ltd.
General Hospital · 107d
Cleared Oct 10, 2024
ProSeal™ In Line Pump Set (423850)
K241735
Epic Medical Pte. , Ltd.
General Hospital · 115d
Cleared Aug 30, 2024
ToxiSeal™ Vial Adaptor
K241823
Epic Medical Pte. , Ltd.
General Hospital · 67d
Cleared Jun 21, 2024
ToxiSeal™ Vial Adaptor with External Flip Balloon
K241476
Epic Medical Pte. , Ltd.
General Hospital · 28d
Cleared May 21, 2024
ProSeal™ Injection Site Extended Male Luer Lock (422140)
K240433
Epic Medical Pte. , Ltd.
General Hospital · 97d
Cleared Mar 28, 2024
ProSeal™ Injector Plus (Model no. 421050)
K240171
Epic Medical Pte. , Ltd.
General Hospital · 66d
Cleared Jan 11, 2024
ToxiSeal Vial Adapter with External Balloon
K222929
Epic Medical Pte. , Ltd.
General Hospital · 472d
Cleared Mar 24, 2023
BD Texium™ Closed Male Luer
K223076
Care Fusion
General Hospital · 175d

About Product Code ONB - Regulatory Context

510(k) Submission Activity

41 total 510(k) submissions under product code ONB since 2013, with 41 receiving FDA clearance (average review time: 198 days).

Submission volume has increased in recent years - 12 submissions in the last 24 months compared to 6 in the prior period - suggesting growing market activity in this device classification.

FDA Review Time

Recent submissions under ONB have taken an average of 111 days to reach a decision - down from 234 days historically, suggesting improved FDA processing for this classification.

ONB devices are reviewed by the General Hospital panel. Browse all General Hospital devices →